Clinical

Complex Lipids

Our complex lipids include phospholipid concentrates and gangliosides.

Phospholipid Concentrates

Our phospholipid concentrates are milk-derived complex lipid isolates produced by the extraction of phospholipids from milk. Milk-derived phospholipids are structurally more comparable to human phospholipids than those derived from vegetable sources and contain unique components such as sphingomyelin, which is not found in plants.

Our Phospholipid Concentrate 700 contains phospholipid levels 4000 times that of native milk, including high levels of sphingomyelin, an important phospholipid for cell growth and regulation. Our phospholipid products are suited for use in infant formula, follow-on-formula, nutritional products, surface coating and dermatological applications.

Gangliosides

Our ganglioside products are milk-derived ganglioside concentrates suited for use in infant formula, dietary supplements and nutritional products. Ganglioside is the generic term used for acidic glycolipids (sugar containing lipids). Gangliosides occur naturally in the milk fat globule membrane in human and bovine milk and are integral components of cell membranes.

Fonterra’s Ganglioside 500 is an excellent source of mono-sialo ganglioside 3 (GM3), di-sialo ganglioside (GD3) and phosphatidyl serine. Each of these components has been linked to learning and development. GM3, the predominant ganglioside in human milk after the 40th day of lactation, plays an important role in cell growth and development, and possess immune supporting properties. 1,2,3 †  

Animal data further suggest that physiological levels of dietary gangliosides increase the ether phospholipid content of normal intestinal mucosa. These data point to a role for dietary gangliosides in helping maintain gut health and balance. 4

 

1. Takawmizawa K et al. Selective changes in gangliosides of human milk during lactation: a molecular indicator for the period of lactation. Eliseiver Science Publishers B.V. (Biomedical Division).

2. Reuda R, et al. New Data on Content and Distribution of Gangliosides in Human Milk. Biol Chem Hoppe-Seyler. 1995:376;723-7.

3. Reuda R. et al. Role of Dietary Gangliosides in Early Infancy. Nutrition and Biochemistry of phospholipids Ed. Bernard F. Szuhaj and Willem van Nieuwenhuyzen.2003.01-16.

4. E.J. Park, M. Suh, B. Thomson, K. Ramanujam, K. Steiner, E. Lien, A.B.R. Thomson, M.T. Clandinin. (2005) Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. Glycobiology. 15 (10): 935-942.

† This statement has not been evaluated by the US Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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